Our Expertise

Allergenix has extensive technical capabilities and capacity in the following areas:

1. Ethical animal management facilities.
2. Screening for allergen-specific IgE levels.
3. Bronchoscopic techniques allowing segmental lung-delivery of allergens/drugs and comparison within the same sheep.
4. Drug and allergen delivery by aerosol.
5. Extensive experience with histological and immunological techniques:
• Inflated lung fixation to preserve morphology
• Frozen sections and immunohistology
• Detection of mucosal and systemic Ab isotypes
• Morphometric analysis
• Measurement of cytokines
• Flowcytometry of BAL and peripheral blood
6. Lung mechanics analysis in awake animals:
• Lung compliance
• Airway resistance
• Tidal volumes and breathing rates
• Airway hyperreactivity